- Hypercube, Inc.
 - Gainesville - Offers sophisticated molecular modelling software packages uniting 3D visualisation and animation with quantum chemical calculations, molecular mechanics, and dynamics. - Endymion Corporation
- Gainesville - Endymion provides quality custom engineering in the areas of software, networking, and web.
- Flashworks
- Gainesville - Maker of software for calculating electrical service loads for all types of occupancies; adheres to the requirements of the National Electrical Code.
- Coral Acoustics
- Gainesville - Metronome software for Windows 95/NT. Site includes free demo.
- Computer Network Experts, Inc.
- Gainesville - Specialising in LAN/Internet integration.
- Aliken Publications
- Gainesville - Computer consulting, graphic design and web hosting.
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