- Laboratory for Computer Science
 - Advanced Network Architecture Group
- Alewife Project
- Large-scale multiprocessor that integrates cache-coherent, distributed shared memory, and user-level message-passing in a single integrated hardware framework.
- Artificial Intelligence Laboratory (5)
- Clinical Decision Making Group
- Research group that works on medical applications of computer science and AI
- Computational Geonomics Research Group
- Computer Graphics Group
- Houses several research groups working on the latest graphics technology.
- Computer Science and Artificial Intelligence Laboratory (CSAIL)
- Conducts primary research in architecture, networks, language, complex adaptive systems, and other areas of computation and artificial intelligence.
- Intelligent Information Infrastructure Project
- Extremely general system for distributing and retrieving information that will work over major Internet protocols.
- MIT Media Laboratory (8)
- Networked Computer Science Technical Reports Library (NCSTRL)
- International collection of computer science technical reports from CS departments and industrial and government research laboratories, made available for noncommercial and educational use.
- Parallel and Distributed Operating Systems Group (1)
- Project Oxygen
- Bringing abundant computation and communication, as pervasive and free as air, naturally into people's lives.
- Sensory Communication Group
- Spoken Language Systems Group (2)
- TEK Project, The
- Working to build a low-connectivity search engine for use by people at the far side of a bad telephone connection.
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