- Ockham's Slice
 - Comic about a disillusioned lawyer moves to the country, where befriends a skunk, a mole, and a porcupine. - Odin and Friends
- Daily webcomics by Scott Svatos, loosely based on Norse mythology and featuring the adventures of Odin, Thor, Loki, Baldur, Slippy, and more.
- Off the Mark
- Daily comic panel.
- Oh My Gods!
- A pagan-based comic strip for the polytheistic masses.
- On The Fastrack
- On the Psychologist's Couch
- Cartoons featuring more-or-less actual quotes from patients.
- Once Were Stars
- The daily adventures of a music store owner.
- Onion Head Monster
- Features comics, paintings, animation action, stories, and more.
- Opus (3)
- Order of the Stick, The
- Online comic strip about a group of Dungeons and Dragons type characters. By Rich Burlew.
- Orneryboy
- An endless drama of dysfunction. A comic strip by Michael Lalonde.
- Outtake
- Comic strip by Ed Colley and Mark Pothier focusing on pop culture and the national obsession with the entertainment industry.
- Over The Edge by Dan Reynolds
- Over the Hedge
- Official site of the comic strip Over the Hedge by Michael Fry and T. Lewis that inspired the 2006 animated movie about "suburban living from the perspective of the animals who lived there first." Features an archive of past editions of the comic.
- Overboard
- Overcompensating
- Jeffrey Rowland's true Oklahoma stories updated daily.
- Ozy and Millie
- Following the adventures of an Arctic fox and an aardvark. By David Craig Simpson.
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